Functionalized Fullerene for Inhibition of SARS‐CoV‐2 Variants (Small 15/2023). Issue 15 (12th April 2023)

• Record Type: Journal Article
• Authors: Page, Taylor M.; Nie, Chuanxiong; Neander, Lenard; Povolotsky, Tatyana L.; Sahoo, Anil Kumar; Nickl, Philip; Adler, Julia M.; Bawadkji, Obida; Radnik, Jörg; Achazi, Katharina; Ludwig, Kai; Lauster, Daniel; Netz, Roland R.; Trimpert, Jakob; Kaufer, Benedikt; Haag, Rainer; Donskyi, Ievgen S.
• Is Part Of: Small. Volume 19:Issue 15(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-04-12
• Subjects: covalent functionalization -- fullerene -- SARS‐CoV‐2 -- sulfated materials -- virus inhibition; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.202370093
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract : Inhibition of SARS‐CoV‐2 Variants In the article number 2206154, Ievgen S. Donskyi and co‐workers describe effective SARS‐CoV‐2 inhibitor. Low molecular weight polyglycerol sulfate works in tandem with a single hydrophobic fullerene to prevent the infection in vitro. Investigated through plaque reduction assays, microscale thermophoresis (MST) binding studies, and molecular dynamics (MD) simulations, fullerene appears to nestle in to a solvent accessible hydrophobic pocket on the S1 spike protein.