Advances in non‐palladium‐catalysed Stille couplings. (14th September 2021)

• Record Type: Journal Article
• Authors: Aleena, Mary Baby; Philip, Rose Mary; Anilkumar, Gopinathan
• Is Part Of: Applied organometallic chemistry. Volume 35:Number 12(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-09-14
• Subjects: alkyl/aryl halides -- cross‐coupling -- organostannanes -- Stille coupling -- transition metal catalysis; Organometallic chemistry -- Periodicals; Organometallic compounds -- Periodicals; 547.05
• DOI: 10.1002/aoc.6430
• Languages: English
• ISSNs: 0268-2605

Abstract

Abstract : Stille coupling is regarded as a powerful tool in the synthesis of a wide range of functionalised C–C bonds due to the high stability, availability and broad functional group compatibility of the organostannanes. This is the first review solely focused on the role of the non‐palladium transition metals in Stille coupling with emphasis on their catalytic capacity and mechanistic details. Several transition metals including Mn, Ni, Cu, Rh, Pt, and Au are found highly efficient in the coupling with Cu having the largest reports. Importantly, Cu‐catalysed Stille couplings formed the key stages in the synthesis of therapeutic molecules like 4( S )‐11‐diHDHA and Spliceostatin derivatives. Greener protocols including reusable heterogeneous catalytic systems are promising alternatives and some have even shown dominance over Pd catalysts. This review comprises all available literature on non‐palladium Stille coupling up to June 2021. Abstract : Palladium‐catalysed Stille couplings has got greater attention owing to their applicability in the construction of heavily functionalised C–C adducts, which are significant in natural product synthesis and other related fields. Non‐palladium Stille couplings are a better choice for organic synthesis since they are more cost‐effective, less toxic, and some having superior catalytic efficiency compared with conventional techniques utilising Pd. In the present review, we focus on the developments in non‐palladium Stille couplings until 2021.