Efficacy and safety of various oral regimens (three oral doses) and schedules (daily v. monthly) of cholecalciferol in North Indian adults with low vitamin D status: evidence from a randomised controlled trial. Issue 10 (28th May 2023)

• Record Type: Journal Article
• Authors: Ganie, Mohd Ashraf; Sidana, Shivani; Baba, Mohammad Salem; Sahar, Tajali; Rashid, Aafia; Asrar, Mir Mahmood; Marwaha, R K; Wani, Ishfaq Ahmad; Misgar, Riyaz A; Wani, Imtiyaz Ahmad
• Is Part Of: British journal of nutrition. Volume 129:Issue 10(2023)
• Page Start: 1732
• Page End: 1739
• Publication Date: 2023-05-28
• Subjects: Vitamin D deficiency -- Tropical regions -- 25 hydroxy vitamin D -- Cholecalciferol -- Intact parathyroid hormones; Nutrition -- Periodicals; 572.4
• DOI: 10.1017/S0007114522002641
• Languages: English
• ISSNs: 0007-1145

Abstract

Abstract: Vitamin D (VD) deficiency (serum 25 hydroxy vitamin D (25(OH)D) concentration of < 20 ng/ml), in endemic proportions, demands a supplementation strategy with optimal dosing regimens. A randomised parallel-group, active-controlled trial was conducted among apparently healthy, VD-deficient subjects, aged 18–60 years who received 600 μg/d (Group A), 1000 μg/d (Group B), 2000 μg/d (Group C) and 60 000 μg/month (Group D) of oral cholecalciferol. The intervention was carried in two phases (I and II) of 12 weeks each, with same dose, separated by a washout phase of 12 weeks. Serum 25(OH)D, intact parathyroid hormones (iPTH), Ca, phosphorous (PO4), alkaline phosphatase (ALP) and spot urine Ca/Cr were measured at baseline, 12, 24 and 36 weeks following the intervention, and adverse events were recorded at each occurrence and at 12, 24 and 36 weeks. A statistically significant time–group interaction was found in serum 25(OH)D concentration ( P < 0·05). Serum 25(OH)D concentration increased significantly from baseline to 12 weeks ( P < 0·05) in all the groups with no change at 24 weeks but further increase at 36 weeks ( P < 0·05). At the end of the study, Group C had maximum increment in serum 25(OH)D concentration, while as Groups C and D (95 %, and 90 %) had higher proportion of subjects VD sufficient than Groups A and B (65 % and 78 %) ( P < 0·05). No significant time–dose interactions were observed in serum iPTH, Ca, PO4 and ALP or urine Ca/Cr ratio. Three subjects (two in Group C and one in Group D) developed transient hypercalciuria. Supplementation with daily 2000 μg or monthly 60 000 μg of oral cholecalciferol among adults seems optimal and safe.