Clinical and Pathological Features of Congenital Hepatic Hemangioma in Children: A Retrospective Analysis. (4th March 2023)

• Record Type: Journal Article
• Authors: Wen, Rong; Zhou, Zheng-Zhen; Chen, Wei-Jian
• Is Part Of: Fetal and pediatric pathology. Volume 42:Number 2(2023)
• Page Start: 198
• Page End: 206
• Publication Date: 2023-03-04
• Subjects: Congenital hepatic hemangioma -- Glut1 -- abnormal vascular proliferation; Pathology, Molecular -- Periodicals; Pediatrics -- Periodicals; Molecular biology -- Periodicals; Pediatric pathology -- Periodicals; Fetal Diseases -- pathology -- Periodicals; Infant, Newborn, Diseases -- pathology -- Periodicals; Pediatrics -- Periodicals; 618.92007
• DOI: 10.1080/15513815.2022.2114300
• Languages: English
• ISSNs: 1551-3815

Abstract

Abstract: Objective: We reviewed our experience with congenital hepatic hemangiomas (CHH) to assess the effectiveness of our treatment strategies. Methods: Clinical and pathologic features of children with CHH were reviewed. Results: Twenty-two cases of CHH were collected, 17 were resected and 5 were followed until resolution. In 17 with alpha-feto-protein (AFP) levels, 9 were elevated with 5 decreasing to normal before surgery. In six with tumors under 3 cm, five regressed between 1 and 13 months, one required removal 5 years after initial diagnosis. Postoperative histopathology of 17 cases showed abnormal vascular hyperplasia without lobular architecture. CD34 was expressed in all tumors, glucose transporter 1(Glut1) was negative. Conclusion: If the tumor is less than 3 cm, AFP is normal and there are no obvious complications, the lesion can be followed with regular assessment imaging. Surgical resection is an option in tumors less than 3 cm which have not regressed over time.