A parylene-mediated plasmonic–photonic hybrid fiber-optic sensor and its instrumentation for miniaturized and self-referenced biosensing. Issue 8 (20th March 2023)

• Record Type: Journal Article
• Authors: Li, Xin; Wang, Nanxi; Wang, Fei; Liu, Jinlong; Shi, Yimin; Jiang, Jiahong; Liu, Hongyao; Li, Mingxiao; Zhang, Lina; Zhang, Wenchang; Zhao, Yang; Zhang, Lingqian; Huang, Chengjun
• Is Part Of: Analyst. Volume 148:Issue 8(2023)
• Page Start: 1672
• Page End: 1681
• Publication Date: 2023-03-20
• Subjects: Chemistry, Analytic -- Periodicals; 543
• DOI: 10.1039/d3an00028a
• Languages: English
• ISSNs: 0003-2654

Abstract

Abstract : A miniaturized fiber-optic sensor system for real-time biosensing with RGB LED as the light source and photodiode as the receiver. Abstract : With the development of advanced nanofabrication techniques over the past decades, different nanostructure-based plasmonic fiber-optic sensors have been developed and have presented a low limit of detection for various biomolecules. However, owing to both the dependence on complex equipment and the trade-off between the fabrication cost and sensing performance, nanostructured plasmonic fiber-optic sensors are rarely used outside laboratories. To facilitate wider application of the plasmonic fiber-optic sensors, a parylene-mediated hybrid plasmonic–photonic cavity-based sensor was developed. Compared with a similar plasmonic sensor which only works in the plasmonic mode, the proposed hybrid sensor shows a higher reproducibility (CV < 2.5%) due to its resistance to fabrication variations. Meanwhile, a self-referenced detection mechanism and a novel miniaturized system were developed to adapt to the hybrid resonance sensor. The entire system only has a weight of 263 g, and a size of 12 cm × 10 cm × 8 cm, and is especially suitable for outdoor applications in a handheld manner. In experiments, a high refractive index sensitivity of 3.148 RIU −1 and real-time biomolecule monitoring at nanomolar concentrations were achieved by the proposed system, further confirming the potential of the miniaturized system as a candidate for point-of-care health diagnostics outside laboratories.