Radical-mediated remote migration of quinoxalinones. Issue 30 (28th March 2023)

• Record Type: Journal Article
• Authors: Chang, Chenyang; Zhang, Qi; Wu, Xinxin; Zhu, Chen
• Is Part Of: Chemical communications. Volume 59:Issue 30(2023)
• Page Start: 4499
• Page End: 4502
• Publication Date: 2023-03-28
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d2cc06887g
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Described herein is the first example of radical-mediated remote quinoxalinone migration. Abstract : Disclosed herein is the first example of radical-mediated remote migration of quinoxalinones. The quinoxalinonyl-functionalization of alkenes employs the quinoxalinone-substituted tertiary bishomoallylic alcohols as substrates, proceeds through intramolecular 1, 4-quinoxalinone migration, and gives rise to complex γ-quinoxalinone-substituted aliphatic ketones. A set of external radicals is compatible with this method. The protocol features broad tolerance of functional groups, good adaptability to various external radicals and high product diversity, and opens a new door for the synthesis of quinoxalinone derivatives.