Hepatitis E Virus Seroprevalence is Associated with Neurodegenerative Disorders in Older People with Dementia: A Case-Control Study. (27th June 2022)

• Record Type: Journal Article
• Authors: Pérez-García, Felipe; Vázquez-Morón, Sonia; Burgueño-García, Iván; Muñoz-Gómez, María José; Zea-Sevilla, María Ascensión; Calero, Miguel; Martínez, Isidoro; Rábano, Alberto; Resino, Salvador
• Is Part Of: Journal of infectious diseases. Volume 227:Number 7(2023)
• Page Start: 873
• Page End: 877
• Publication Date: 2022-06-27
• Subjects: Hepatitis E virus -- seroprevalence -- Alzheimer -- vascular pathology -- neurodegenerative disorders -- older people; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiac268
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: In this case-control study, we evaluated the association between serum antibodies against hepatitis E virus (HEV) and central nervous system (CNS) neurodegenerative disorders (NDs) in older people with dementia. The presence of anti-HEV antibodies was related to a higher adjusted odds ratio (aOR) of having CNS NDs by neuropathological diagnosis (aOR, 2.13; P = .007) and clinical/neuropathological diagnosis (1.84; P = .02). Besides, serum anti-HEV antibodies were directly related to neuropathological injury (higher vascular pathology [aOR, 1.97; P = .006]) and higher probability of Alzheimer-type pathology (1.84; P = .02). In conclusion, the presence of anti-HEV antibodies was related to higher odds of CNS NDs and neuropathological injury in older people. Abstract : Hepatitis E virus (HEV) infection can produce extrahepatic manifestations, including neurological disorders. We found that HEV seroprevalence was associated with central nervous system neurodegenerative disorders (mainly Alzheimer-type) and vascular pathology in the brains of older people. Graphical Abstract: Graphical Abstract