The 2019–2020 Dengue Fever Epidemic: Genomic Markers Indicating Severity in Dominican Republic Children. Issue 3 (20th December 2022)

• Record Type: Journal Article
• Authors: Simpson, Brittany N; Mejía Sang, Miguel E; Collado Puello, Yonairy; Diaz Brockmans, Elvira J; Díaz Soto, María F; Rivera Defilló, Stephanie M; Taveras Cruz, Karla M; Santiago Pérez, Javier O; Husami, Ammar; Day, Melissa E; Pilipenko, Valentina; Mena, Rafael; Mota, Cesár; Hostetter, Margaret K; Muglia, Louis J; Schlaudecker, Elizabeth; Gonzalez del Rey, Javier; Martin, Lisa J; Prada, Carlos E
• Is Part Of: Journal of the Pediatric Infectious Diseases Society. Volume 12:Issue 3(2023)
• Page Start: 169
• Page End: 172
• Publication Date: 2022-12-20
• Subjects: children -- dengue fever -- genomic risk factors -- interferon; Communicable diseases in children -- Periodicals; Children -- Diseases -- Periodicals; 618.929
• DOI: 10.1093/jpids/piac136
• Languages: English
• ISSNs: 2048-7193

Abstract

Abstract: We performed an observational cohort study to assess associations between genetic factors of dengue fever (DF) severity in children in the Dominican Republic. A total of 488 participants had serologically confirmed DF. We replicated the association between the IFIH1 gene (rs1990760) and severe DF ( n = 80/488, p = 0.006) and identified novel associations needing further investigation. Abstract : We performed an observational cohort study to assess associations between genetic risk factors and dengue fever (DF) severity in children in the Dominican Republic. Significant risk of severe DF was associated with polymorphisms in the IFIH1 gene.