Evaluation of the effectiveness of alginate-based hydrogels in preventing peritoneal adhesions. (21st March 2023)

• Record Type: Journal Article
• Authors: Meng, Zhu; Wang, Han; Liu, Yu; Yang, Minyi; Zeng, Hang; Han, Qianqian
• Is Part Of: Regenerative biomaterials. Volume 10(2023)
• Publication Date: 2023-03-21
• Subjects: peritoneal adhesions -- sodium alginate hydrogel -- mesothelial cells -- TGF-β1; Biomedical materials -- Periodicals; Regenerative medicine -- Periodicals; 610.284
• DOI: 10.1093/rb/rbad017
• Languages: English
• ISSNs: 2056-3418

Abstract

Abstract: Infertility and intestinal blockage are just two examples of the postoperative consequences that can arise from peritoneal damage, which can also result in severe peritoneal fibrosis and peritoneal adhesions. Peritoneal adhesions are still not effectively treated, and both pharmaceutical therapy and biomaterial barriers have only had modest preventative effects. In this work, we looked into the effectiveness of in-place injectable sodium alginate hydrogel for peritoneal adhesion prevention. The findings demonstrated that sodium alginate hydrogel promoted human peritoneal mesothelial cell proliferation and migration, prevented peritoneal fibrosis by suppressing the production of transforming growth factor-β1, and, most importantly, promoted mesothelium self-repair. These findings imply that this brand-new sodium alginate hydrogel is a good candidate material for peritoneal adhesion prevention. Graphical abstract: