Sustained upregulation of widespread hippocampal–neocortical coupling following memory encoding. (3rd October 2022)

• Record Type: Journal Article
• Authors: Folvik, Line; Sneve, Markus H; Ness, Hedda T; Vidal-Piñeiro, Didac; Raud, Liisa; Geier, Oliver M; Walhovd, Kristine B; Fjell, Anders M
• Is Part Of: Cerebral cortex. Volume 33:Number 8(2023)
• Page Start: 4844
• Page End: 4858
• Publication Date: 2022-10-03
• Subjects: hippocampus -- functional connectivity -- fMRI -- reactivation -- systems consolidation; Cerebral cortex -- Periodicals; Brain -- Periodicals; 612.825
• DOI: 10.1093/cercor/bhac384
• Languages: English
• ISSNs: 1047-3211

Abstract

Abstract: Systems consolidation of new experiences into lasting episodic memories involves hippocampal–neocortical interactions. Evidence of this process is already observed during early post-encoding rest periods, both as increased hippocampal coupling with task-relevant perceptual regions and reactivation of stimulus-specific patterns following intensive encoding tasks. We investigate the spatial and temporal characteristics of these hippocampally anchored post-encoding neocortical modulations. Eighty-nine adults participated in an experiment consisting of interleaved memory task- and resting-state periods. We observed increased post-encoding functional connectivity between hippocampus and individually localized neocortical regions responsive to stimuli encountered during memory encoding. Post-encoding modulations were manifested as a nearly system-wide upregulation in hippocampal coupling with all major functional networks. The configuration of these extensive modulations resembled hippocampal–neocortical interaction patterns estimated from active encoding operations, suggesting hippocampal post-encoding involvement exceeds perceptual aspects. Reinstatement of encoding patterns was not observed in resting-state scans collected 12 h later, nor when using other candidate seed regions. The similarity in hippocampal functional coupling between online memory encoding and offline post-encoding rest suggests reactivation in humans involves a spectrum of cognitive processes engaged during the experience of an event. There were no age effects, suggesting that upregulation of hippocampal–neocortical connectivity represents a general phenomenon seen across the adult lifespan.