Progress and prospects of polysaccharide-based nanocarriers for oral delivery of proteins/peptides. (15th July 2023)

• Record Type: Journal Article
• Authors: Yuan, Haoyang; Guo, Chen; Liu, Lei; Zhao, Linxuan; Zhang, Yu; Yin, Tian; He, Haibing; Gou, Jingxin; Pan, Bochen; Tang, Xing
• Is Part Of: Carbohydrate polymers. Volume 312(2023)
• Publication Date: 2023-07-15
• Subjects: ADH adipic dihydrazide -- ALG alginate -- BSA bovine serum albumin -- CaP calcium phosphate -- ChS chondroitin sulfate -- CLSM confocal scanning microscopy -- CMC carboxymethylcellulose -- CMCD carboxymethyl-cyclodextrin -- CMCS carboxymethyl chitosan -- CMS anionic carboxymethyl starch -- ConA Concanavalin A -- CS chitosan -- CSA carboxymethylated short-chain amylose -- CSC core shell corona nanolipoparticles -- CSK CSKSSDYQC -- CS-CSK chitosan-CSKSSDYQC -- CS-FA folic acid-modified chitosan -- Dex Dextran -- DS degree of substitution -- EE encapsulation efficiency -- GI Gastrointestinal tract -- HA hyaluronic acid -- HAS human serum albumin -- HA-SH thiolated hyaluronic acid -- HES hydroxyethyl starch -- HPMC hydroxypropyl methylcellulose -- HS heparin sodium -- HTCC N-(2-hydroxypropyl)-3-trimethyl ammonium chloride modified chitosan -- ILS intestinal lymphatic system -- LMWC low molecular weight chitosan -- MAP modified apple polysaccharide -- mPEG polyethylene glycol monomethyl ether -- MW molecular weight -- NAC N-acetyl-l-cysteine -- NPs nanoparticles -- PA pharmacological availability -- PEs Polyelectrolytes -- PECs Polyelectrolyte complexes -- PEMs polyelectrolyte multilayers -- P-gp P-glycoprotein -- PTCS preactivated thiolated chitosan -- PVP poly (N-vinyl pyrrolidone) -- QAS cationic quaternary ammonium starch -- SCG short-chain glucans -- TCS thiolated chitosan -- TJ tight junction -- TMC, N N, N-trimethyl chitosan -- TMC-CSK CSK peptide modified TMC -- TMC-Cys TMC-cysteine conjugate -- TPP sodium trimetaphosphate -- ZP zeta potential; Polysaccharides -- Proteins and peptides -- Oral bioavailability -- Nanoparticles -- Interaction force; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2023.120838
• Languages: English
• ISSNs: 0144-8617

Abstract

Abstract: The oral route has long been recognized as the most preferred route for drug delivery as it offers high patient compliance and requires minimal expertise. Unlike small molecule drugs, the harsh environment of the gastrointestinal tract and low permeability across the intestinal epithelium make oral delivery extremely ineffective for macromolecules. Accordingly, delivery systems that are rationally constructed with suitable materials to overcome barriers to oral delivery are exceptionally promising. Among the most ideal materials are polysaccharides. Depending on the interaction between polysaccharides and proteins, the thermodynamic loading and release of proteins in the aqueous phase can be realized. Specific polysaccharides (dextran, chitosan, alginate, cellulose, etc.) endow systems with functional properties, including muco-adhesiveness, pH-responsiveness, and prevention of enzymatic degradation. Furthermore, multiple groups in polysaccharides can be modified, which gives them a variety of properties and enables them to suit specific needs. This review provides an overview of different types of polysaccharide-based nanocarriers based on different kinds of interaction forces and the influencing factors in the construction of polysaccharide-based nanocarriers. Strategies of polysaccharide-based nanocarriers to improve the bioavailability of orally administered proteins/peptides were described. Additionally, current restrictions and future trends of polysaccharide-based nanocarriers for oral delivery of proteins/peptides were also covered. Graphical abstract: Unlabelled Image