NAD+ depletion and defense in bacteria. Issue 5 (May 2023)

• Record Type: Journal Article
• Authors: Wang, Meng; Ji, Qing; Liu, Peng; Liu, Yukun
• Is Part Of: Trends in microbiology. Volume 31:Issue 5(2023)
• Page Start: 435
• Page End: 438
• Publication Date: 2023-05
• Subjects: Microbiology -- Periodicals; Infection -- Periodicals; Virulence (Microbiology) -- Periodicals; Infection -- Periodicals; Microbiology -- Periodicals; Virulence -- Periodicals; Microbiologie -- Périodiques; Infection -- Périodiques; Virulence (Microbiologie) -- Périodiques; Infection; Microbiology; Virulence (Microbiology); 579
• DOI: 10.1016/j.tim.2022.06.002
• Languages: English
• ISSNs: 0966-842X

Abstract

Abstract : Depletion of nicotinamide adenine dinucleotide (NAD + ), an important regulator of cellular energy metabolism, is a common strategy in immune-mediated cell death (ICD) in both prokaryotes and eukaryotes. Recent studies have revealed how bacteria use NAD + depletion to protect against phages, providing insight into how eukaryotic ICD might have evolved.