Diffuse optical detection of global cerebral ischemia in an adult porcine model. Issue 4 (4th December 2022)

• Record Type: Journal Article
• Authors: Fu, Chuhua; Wang, Detian; Wang, Long; Zhu, Liguo; Li, Zeren; Chen, Tunan; Feng, Hua; Li, Fei
• Is Part Of: Journal of biophotonics. Volume 16:Issue 4(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-12-04
• Subjects: acute ischemic stroke -- blood flow -- diffuse correlation spectroscopy -- near‐infrared spectroscopy; Photonics -- Periodicals; Optical materials -- Periodicals; Optics -- Periodicals; Medical instruments and apparatus -- Periodicals; 621.3605
• DOI: 10.1002/jbio.202200168
• Languages: English
• ISSNs: 1864-063X

Abstract

Abstract: Rapid screening for ischemic strokes in prehospital settings may improve patient outcomes by allowing early deployment of vascular recanalization therapies. However, there are no low‐cost and convenient methods that can assess ischemic strokes in such a setting. Diffuse correlation spectroscopy (DCS) is a promising method for continuous, noninvasive transcranial monitoring of cerebral blood flow. In this study, we used a DCS system to detect cerebral hemodynamics before and after acute ischemic stroke in pigs. Seven adult porcines were chosen to establish ischemic stroke models via bilateral common carotid artery ligation ( n = 5) or air emboli ( n = 2). The results showed a significant difference in blood flow index (BFI) between the normal and ischemic groups. Relative blood flow index (rBFI) exhibited excellent results. Therefore, the diffuse optical method can assess the hemodynamic changes in acute cerebral ischemic stroke onset in pigs, and rBFI may be a promising biomarker for identifying cerebral ischemic stroke. Abstract : For rapid screening for acute ischemic stroke in prehospital settings, a hybrid diffuse optical device, which combines near‐infrared spectroscopy and diffuse correlation spectroscopy is used to monitor cerebral hemodynamics before and after ischemic stroke in porcines. The results suggest that the diffuse optical method can detect the hemodynamic changes in porcines in the first few hours of ischemic stroke onset, and relative changes in the blood flow index may be a promising biomarker to identify acute ischemic stroke.