Autophagy and kidney aging. (May 2023)

• Record Type: Journal Article
• Authors: Minami, Satoshi; Yamamoto, Takeshi; Yamamoto-Imoto, Hitomi; Isaka, Yoshitaka; Hamasaki, Maho
• Is Part Of: Progress in biophysics and molecular biology. Volume 179(2023)
• Page Start: 10
• Page End: 15
• Publication Date: 2023-05
• Subjects: Autophagy -- Lysosome -- Kidney aging -- Chronic kidney disease; AKI acute kidney injury -- Bnip3 BCL2-interacting protein 3 -- CKD chronic kidney disease -- Foxo3a forkhead box O3 -- ROS reactive oxygen species -- Rubicon RUN and cysteine-rich domain containing Beclin 1-interacting protein -- SASPs senescence-associated secretory phenotypes; Biophysics -- Periodicals; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular Biology -- Periodicals; Biophysique -- Périodiques; Biochimie -- Périodiques; 571.4
• DOI: 10.1016/j.pbiomolbio.2023.02.005
• Languages: English
• ISSNs: 0079-6107

Abstract

Abstract: Autophagy is a highly conserved intracellular degradation system in eukaryotes that maintains cellular and tissue homeostasis. Upon autophagy induction, cytoplasmic components are engulfed by a double-membrane organelle called the autophagosome that fuses with a lysosome to degrade its contents. In recent years, it has become clear that autophagy becomes dysregulated with aging, which leads to age-related diseases. Kidney function is particularly prone to age-related decline, and aging is the most significant risk factor for chronic kidney disease. This review first discuss the relationship between autophagy and kidney aging. Second, we describe how age-related dysregulation of autophagy occurs. Finally, we discuss the potential of autophagy-targeting drugs to ameliorate human kidney aging and the approaches necessary to discover such agents.