Pathological implications of cellular stress in cardiovascular diseases. (May 2023)

• Record Type: Journal Article
• Authors: Ulaganathan, Thennavan; Perales, Selene; Mani, Saiprahalad; Baskhairoun, Boula A.; Rajasingh, Johnson
• Is Part Of: International journal of biochemistry & cell biology. Volume 158(2023)
• Publication Date: 2023-05
• Subjects: MI Myocardial infraction -- Drp-1 Dynamin related protein-1 -- Dox Doxorubicin -- mtUPR Mitochondrial unfolded protein response -- HGPS Hutchinson-Gilford progeria syndrome -- ER Endoplasmic reticulum -- ERAD Endoplasmic reticulum associated degradation -- UPR Unfolded protein response -- CVDs Cardiovascular diseases -- ROS Reactive oxygen species -- iCM Inner cell mass -- VEGF Vascular endothelial growth factor -- iNOS Induced nitric oxide synthetase -- IL Interleukin -- DNA Deoxyribonucleic acid -- RNA Ribonucleic Acid -- LncRNA Long non-coding RNA -- MALAT1 Metastasis associated lung adenocarcinoma transcript 1 -- PI3K Phosphoinositide 3-kinases -- Akt Ak strain transforming/Protein kinase B -- FUS1 Fused in sarcoma -- Mff Mitochondrial fission factor -- MiD Mitochondrial dynamics protein -- OPA1 Optic atrophy-1 -- Mfn Mitofusin -- MAM Mitochondiral associated membrane -- AMP Adenosine monophosphate -- AMPK AMP-activated protein kinase -- SUMO Small ubiquitin-like Modifier -- OMM Outer mitochondrial membrane -- IFN-γ Interferon-gamma -- FGF Fibroblast growth factor -- TNF-α Tumor necrosis factor-alpha -- LCAD Long-chain acyl-CoA dehydrogenase -- MCAD Medium-chain acyl-CoA dehydrogenase -- CPT-1 Carnitine palmitoyltransferase 1 -- ACSL-1 Acyl-CoA synthetase-1 -- PTEN Phosphatase and tensin homolog -- PINK1 PTEN-induced kinase 1 -- PP2A Protein phosphatase 2A -- TRIM21 Tripartite motif containing-2 -- p62k protein 62 kinase -- KEAP1 Kelch like ECH associated protein 1 -- Nrf-2 Nuclear respiratory factor 2 -- BNIP3 BCL2 interacting protein 3 -- LC3 Microtubule-associated protein light chain 3 -- OXPHOS Oxidative phosphorylation -- CHOP CCAAT-enhancer-binding protein homologous protein -- CLPP Caseinolytic mitochondrial matrix peptidase proteolytic subunit -- LONP1 Lon protease-1 -- ATFS-1 Activating transcription factor associated with stress—1 -- MTS mitochondrial targeting sequence -- NLS Nuclear localization signals -- ISR Integrated stress response -- PERK RNA-dependent protein kinase (PKR)-like ER kinase -- PKR Protein kinase RNA -- GCN2 General controlled nonrepressed-2 -- HRI Heme-regulated inhibitor -- eIF2α Eukaryotic initiation factor-2α -- mt Mitochondira -- SIRT Sirtuin -- SKN-1 Skinhead-1 -- PDI Protein disulfide isomerase -- EDEM ERAD-enhancing α-mannosidase-like proteins -- SERCA Sarco/endoplasmic reticulum Ca2+-ATPase -- STIM1 Stromal interaction molecule 1 -- IR Ischemic- reperfusion -- XBP-1 X-box binding protein-1 -- MANF Mesencephalic Astrocyte-Derived Neurotrophic Factor -- Bcl2 B-cell lymphoma 2 -- TXNIP Thioredoxin-interacting protein -- Pak2 p21-activated kinase-2 -- ERK Extracellular signal-regulated kinase -- mPTP Mitochondrial permeability transition pore -- TFEB Transcription factor EB -- PGC-1α Peroxisome proliferator-activated receptor-gamma coactivator-1α -- Bip Binding immunoglobin protein -- FIH Factor inhibiting HIF -- HIF Hypoxia inducing factor -- PHD Prolyl-4-hydroxylases -- pVHL Von Hippel–Lindau protein -- ART Aryl hydrocarbon receptor nuclear translocator -- ATP Adenosine triphosphate -- CoQ Coenzyme Q -- ETC electron transport chain -- PPARα Peroxisome proliferator activated receptor-α -- PERM1 PGC-1 and ERR-induced Regulator in Muscle 1 -- ERR Estrogen related receptor -- CNH Chronic Continuous Normobaric Hypoxia -- IH Short-term intermittent hypoxia -- SOD Superoxide dismutase -- GPx Glutathione peroxidase -- G6PDH Glucose-6-phosphate dehydrogenase -- AREG Amphiregulin -- EPO Erythropoietin -- DDIT4 DNA damage-inducible transcript 3; Mitochondria -- Endoplasmic reticulum -- Stress -- Unfolded protein response -- Cardiovascular diseases -- Hypoxia; Biochemistry -- Periodicals; Cytology -- Periodicals; Biochemistry -- Periodicals; Cell Biology -- Periodicals; Biochimie -- Périodiques; Cytologie -- Périodiques; Biochimie; Cytologie; Biochemistry; Cytology; Ressource Internet (Descripteur de forme); Périodique électronique (Descripteur de forme); Periodicals; 572.05
• DOI: 10.1016/j.biocel.2023.106397
• Languages: English
• ISSNs: 1357-2725

Abstract

Abstract: Cellular stress has been a key factor in the development of cardiovascular diseases. Major types of cellular stress such as mitochondrial stress, endoplasmic reticulum stress, hypoxia, and replicative stress have been implicated in clinical complications of cardiac patients. The heart is the central regulator of the body by supplying oxygenated blood throughout the system. Impairment of cellular function could lead to heart failure, myocardial infarction, ischemia, and even stroke. Understanding the effect of these distinct types of cellular stress on cardiac function is crucial for the scientific community to understand and develop novel therapeutic approaches. This review will comprehensively explain the different mechanisms of cellular stress and the most recent findings related to stress-induced cardiac dysfunction.