Frontocentral delta-beta amplitude coupling in endometriosis-related chronic pelvic pain. (May 2023)

• Record Type: Journal Article
• Authors: De Blasio, Frances M.; Love, Sapphire; Barry, Robert J.; Wassink, Katherine; Cave, Adele E.; Armour, Mike; Steiner-Lim, Genevieve Z.
• Is Part Of: Clinical neurophysiology. Volume 149(2023)
• Page Start: 146
• Page End: 156
• Publication Date: 2023-05
• Subjects: Endometriosis -- Electroencephalography (EEG) -- Chronic pelvic pain -- Frequency principal components analysis (fPCA) -- Eyes closed resting; Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2023.02.173
• Languages: English
• ISSNs: 1388-2457

Abstract

Highlights: Increased eyes-closed resting delta and beta EEG amplitudes in symptomatic endometriosis vs. age-matched pain-free controls. Decreased posterior alpha amplitude in symptomatic endometriosis that was not linked with chronic pelvic pain. Frontocentral delta-beta amplitude coupling is associated with pelvic pain severity across groups. Abstract: Objective: Endometriosis is associated with neuroplastic changes in cognitive control and pain processing networks. This was the first study to assess eyes-closed resting electroencephalogram (EEG) oscillatory amplitudes in women with endometriosis compared to healthy controls, and explore the relationship with chronic pelvic pain. Methods: Women with endometriosis-related chronic pelvic pain and individually age-matched pain-free controls ( N = 20 per group) documented pelvic pain for 28 days before having continuous EEG recorded during a 2 min eyes closed resting state. Natural frequency components were extracted for each group using frequency principal components analysis. Corresponding components were assessed for group differences and correlated with pain scores. Results: Relative to controls, the endometriosis group had greater component amplitudes in delta (0.5 Hz) and beta (∼28 Hz), and reduced alpha (∼10 Hz). Delta and beta amplitudes were positively associated with pain severity, but only beta maintained this association after delta-beta amplitude coupling was controlled. Conclusions: Enhanced resting delta and beta amplitudes were seen in women with endometriosis experiencing chronic pelvic pain. This delta-beta coupling varied with pelvic pain severity, perhaps reflecting altered cholinergic tone and/or stress reactivity. Significance: Endometriosis-related changes in central pain processing demonstrate a distinct neuronal oscillatory signature detectable at rest.