Changing trends in the incidence and spectrum of cancers between 1990 and 2021 among HIV-infected patients in Busan, Korea. Issue 6 (June 2023)

• Record Type: Journal Article
• Authors: Lee, Soon Ok; Lee, Jeong Eun; Sim, Yong Ki; Lee, Shinwon; Ko, Woo Seog; Kim, Jinmi; Kang, Jin Suk; Son, Hyunjin; Lee, Sun Hee
• Is Part Of: Journal of infection and chemotherapy. Volume 29:Issue 6(2023)
• Page Start: 571
• Page End: 575
• Publication Date: 2023-06
• Subjects: HIV -- Cancer -- Epidemiology; ADC AIDS-defining cancer -- ART antiretroviral therapy -- HBsAg hepatitis B surface antigen -- HBV hepatitis B virus -- HCC hepatocellular carcinoma -- HIV human immunodeficiency virus -- HL Hodgkin lymphoma -- HPVAC human papillomavirus-associated cancer -- hr-HPV high risk-human papillomavirus -- IDU injection drug user -- KS Kaposi sarcoma -- MSM men who have sex with men -- NADC non-AIDS-defining cancer -- NHL non-Hodgkin lymphoma -- PYs person-years -- VRC virus-related cancer -- VR-NADC virus-related non-AIDS-defining cancer -- VU-NADC virus-unrelated non-AIDS-defining cancer -- cART combined antiretroviral therapy -- NSCP National Cancer Screening Program -- HCV hepatitis C virus -- IQR interquartile range -- AIDS acquired immunodeficiency syndrome; Chemotherapy -- Periodicals; Infection -- Periodicals; Communicable diseases -- Chemotherapy -- Periodicals; 615.5805
• DOI: 10.1016/j.jiac.2023.01.018
• Languages: English
• ISSNs: 1341-321X

Abstract

Abstract: Background: Long-term follow-up data on cancer incidence and spectrum among human immunodeficiency virus (HIV)-infected individuals in Korea have been scarce. Material and Methods: This retrospective cohort study included HIV-infected individuals visiting a tertiary care hospital in Busan, South Korea between 1990 and 2021. The observation was divided into 4 periods. The incidence rate was calculated using direct standardization on age and sex, stratified by calendar period. Results: Of the 1, 297 patients, 92 patients (7.1%) were diagnosed with 97 cancers. Excluding 37 patients with prevalent cancer, 1, 260 patients were followed for a total of 8, 803.7 person-years (PYs), and 55 patients developed 60 incident cancers including 5 second primary incident cancers. In men, the AIDS-defining cancer (ADC) incidence decreased from 294.7 per 100, 000 PYs in 1990–1997 to 124.8 per 100, 000 PYs in 2014–2021, while the non-AIDS-defining cancer (NADC) incidence increased from 0 per 100, 000 PYs to 316.5 per 100, 000 PYs during the same period. The proportion of virus-unrelated NADCs (VU-NADCs) increased from 33.3% in 1998–2005 to 49% in 2014–2021. The proportion of human papillomavirus-associated cancers (HPVACs) has recently increased in both ADCs and NADCs. The median time from HIV diagnosis to their first cancer was 1.48 years for ADCs, 6.11 years for VR-NADCs, 8.3 years for VU-NADCs, and 11.5 years for HPVACs. Conclusion: The incidence of NADCs is increasing with the aging of HIV-infected patients, and thus, it is necessary to promote cancer screening and prevention programs.