Cation/proton antiporters: novel structure-driven pharmaceutical opportunities. (May 2023)

• Record Type: Journal Article
• Authors: Masrati, Gal; Kessel, Amit; Ben-Tal, Nir
• Is Part Of: Trends in pharmacological sciences. Volume 44:Number 5(2023)
• Page Start: 258
• Page End: 262
• Publication Date: 2023-05
• Subjects: cation/proton antiporters -- pharmacology -- computational biology; Pharmacology -- Periodicals; Pharmacology -- trends -- Periodicals; Pharmacologie -- Périodiques; Pharmacology; Electronic journals; Periodicals; 615.1
• DOI: 10.1016/j.tips.2023.02.006
• Languages: English
• ISSNs: 0165-6147

Abstract

Abstract: Cation/proton antiporters (CPAs) regulate cells' salt concentration and pH. Their malfunction is associated with a range of human pathologies, yet only a handful of CPA-targeting therapeutics are presently in clinical development. Here, we discuss how recently published mammalian protein structures and emerging computational technologies may help to bridge this gap.