Clinical efficacy of flap transplantation combined with vacuum sealing drainage and methylprednisolone and cyclosporine in the treatment of pyoderma gangrenosum. Issue 5 (2nd November 2022)

• Record Type: Journal Article
• Authors: Hao, Yonghong; He, Juan; Zhao, Zigang; Li, Chengxin; Feng, Zheng
• Is Part Of: International wound journal. Volume 20:Issue 5(2023)
• Page Start: 1491
• Page End: 1497
• Publication Date: 2022-11-02
• Subjects: methylprednisolone -- methylprednisolone -- pyoderma gangrenosum -- vacuum sealing drainage; Wounds and injuries -- Treatment -- Periodicals; Wounds and injuries -- Periodicals; Wound healing -- Periodicals; 617.1005
• DOI: 10.1111/iwj.14003
• Languages: English
• ISSNs: 1742-4801

Abstract

Abstract: This study was aimed to evaluate the clinical efficacy of flap transplantation combined with vacuum sealing drainage and methylprednisolone and cyclosporine in the treatment of ulcer wound of patients with pyoderma gangrenosum (PG). From August 2014 to February 2022, 30 patients with pyoderma gangrenosum ulcer wounds were selected as the research objects and randomly divided into the observation group (n = 12) and the control group (n = 18) in this retrospective study. The patients in observation group were treated with VSD combined with flap transplantation and immunosuppressive agent treatment, while the control group was treated with normal dressing change combined with hormone and cyclosporine. The ulcer wound healing time and dressing change times were compared between the two groups. All the 30 cases of two groups healed after corresponding treatment. The wound healing time of ulcer in the observation group was 35–40 days, with an average healing time of (35.83 ± 1.95) days, and the wound healing time of the control group was 60–200 days, with an average healing time of (44.14 ± 9.67) days. The healing time of observation groups was significantly shorter than that in the control group ( t = 4.652, P < .05). The frequency of dressing change in the observation group was seven–eight times, with an average of (7.17 ± 0.39) times, and the frequency of dressing change in the control group was 75–86 times, with an average of (79.22 ± 3.62) times. The difference between the two groups was significant ( t = 6.214, P < .05). The treatment of VSD combined with flap transplantation and immunosuppressive agent treatment promote ulcer wound healing of pyoderma gangrenosum.