Comparison of three different approaches to very high‐power short‐duration ablation using the QDOT‐MICRO catheter. (11th March 2023)

• Record Type: Journal Article
• Authors: Yamaguchi, Junji; Takigawa, Masateru; Goya, Masahiko; Martin, Claire A.; Yamamoto, Tasuku; Ikenouchi, Takashi; Shigeta, Takatoshi; Nishimura, Takuro; Tao, Susumu; Miyazaki, Shinsuke; Sasano, Tetsuo
• Is Part Of: Journal of cardiovascular electrophysiology. Volume 34:Number 4(2023)
• Page Start: 888
• Page End: 897
• Publication Date: 2023-03-11
• Subjects: catheter ablation -- QDOT‐MICRO -- lesion size; Blood vessels -- Physiology -- Periodicals; Electrophysiology -- Periodicals; Heart -- Physiology -- Periodicals; 612.1
• DOI: 10.1111/jce.15875
• Languages: English
• ISSNs: 1045-3873

Abstract

Abstract: Background/Objectives: The QDOT‐MICRO™ catheter allows very high‐power and short‐duration (vHPSD) ablation. This study aimed to investigate lesion characteristics using different ablation settings. Methods: Radiofrequency applications (90 W/4 s, temperature‐control mode with 55°C or 60°C target) were performed in excised porcine myocardium using three different approaches: single (SA), double nonrepetitive (DNRA), and double repetitive applications (DRA). Applications were performed with an interval of 1 min for DNRA, and without interval for DRA. Results: A total of 480 lesions were analyzed. Lesion depth and volume were largest for DRA followed by DNRA and SA regardless of catheter direction (depth: 3.8 vs. 3.3 vs. 2.6 mm, p < .001 for all comparisons; volume: 176.6 vs. 145.1 vs. 97.0 mm 3, p < .001 for all comparisons). Surface area was significantly larger for DRA than for SA (45.1 vs. 38.3 mm 2, p < .001) and larger for DNRA than for SA (44.5 vs. 38.3 mm 2, p < .001), but was similar between DRA and DNRA (45.1 vs. 44.5 mm 2, p = .54). Steam‐pops more frequently occurred for DRA than for SA (15.6% vs. 4.4%, p = .004) and DNRA (15.6% vs. 6.9%, p = .061), but the incidence was similar between SA and DNRA (4.4% vs. 6.9%, p = 1). Although surface area and lesion volume were larger in lesions with steam‐pops than without steam‐pops (46.5 vs. 38.1 mm 2, p = .018 and 128.3 vs. 96.8 mm 3, p = .068, respectively), lesions were not deeper (pop(+): 2.5 mm vs. pop(−): 2.6 mm, p = .75). Conclusions: DNRA produces larger lesions than SA without increasing the risk of steam‐pops. DRA produces the largest lesions among the three groups, but with an increased risk of steam‐pops. Even with steam‐pops, lesions do not become deeper in vHPSD ablation. Abstract : (Top) Although lesion depth of single radiofrequency applications is small, double RF application with 1 min 'rest' interval may produce deeper lesions without increasing steam‐pops in very high‐power and short‐duration (vHPSD) ablation. (Bottom) Lesion depth does not increase with steam‐pops, suggesting a degree of safety for vHPSD ablation.