Highly Selective and Practical Iron‐Catalyzed Formal Hydrogenation of Epoxides to Primary Alcohols Using Formic Acid. Issue 14 (22nd March 2023)

• Record Type: Journal Article
• Authors: Yao, Yi‐Xuan; Zhang, Hong‐Wei; Lu, Chang‐Bo; Shang, Hong‐Yan; Tian, Yuan‐Yu
• Is Part Of: European journal of organic chemistry. Volume 26:Issue 14(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-03-22
• Subjects: formic acid -- hydrogenation -- iron catalysis -- primary alcohols -- regioselective; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1002/ejoc.202300111
• Languages: English
• ISSNs: 1434-193X

Abstract

Abstract: A highly selective, efficient and practical method for synthesizing primary alcohols was presented. By using cheap Fe(BF4 )2 ⋅ 6H2 O and /tris[2‐(diphenylphosphino)phenyl]phosphine (L1 ) as catalysts with formic acid as hydrogen source, a variety of primary alcohols bearing versatile functional groups could be obtained from both alkyl‐ and aryl‐substituted epoxides under mild conditions. Abstract : Highly selective and efficient synthesis of primary alcohols from epoxides could be achieved under mild conditions by iron catalysis, this process used formic acid as hydrogen source and was suitable for both alkyl‐ and aryl‐substituted epoxides.