This is an interim version of our Electronic Legal Deposit Catalogue-eJournals and eBooks while we continue to recover from a cyber-attack.
Inside Cover: Structural and Mechanistic Studies on Substrate and Stereoselectivity of the Indole Monooxygenase VpIndA1: New Avenues for Biocatalytic Epoxidations and Sulfoxidations (Angew. Chem. Int. Ed. 17/2023). Issue 17 (15th March 2023)
Record Type:
Journal Article
Title:
Inside Cover: Structural and Mechanistic Studies on Substrate and Stereoselectivity of the Indole Monooxygenase VpIndA1: New Avenues for Biocatalytic Epoxidations and Sulfoxidations (Angew. Chem. Int. Ed. 17/2023). Issue 17 (15th March 2023)
Main Title:
Inside Cover: Structural and Mechanistic Studies on Substrate and Stereoselectivity of the Indole Monooxygenase VpIndA1: New Avenues for Biocatalytic Epoxidations and Sulfoxidations (Angew. Chem. Int. Ed. 17/2023)
Abstract : A flavin‐dependent group E monooxygenase ("GEM") has been characterized by crystal‐structure analysis, computational and kinetic studies to reveal substrate binding and mechanistic details for this class of enzymes for the first time. Based on these data, Dirk Tischler, Norbert Sträter, and co‐workers redesigned the substrate binding pocket to synthesize chiral epoxides and sulfoxides with high stereoselectivity, a true treasure of molecular gems, as described in their Research Article (e202300657) .