Nano-vaccines for gene delivery against HIV-1 infection. (31st December 2023)

• Record Type: Journal Article
• Authors: Li, Shuang; Zhang, Meng-Yue; Yuan, Jie; Zhang, Yi-Xuan
• Is Part Of: Expert review of vaccines. Volume 22:Number 1(2023)
• Page Start: 315
• Page End: 326
• Publication Date: 2023-12-31
• Subjects: HIV-1 -- Nano-vaccine -- immune response -- gene delivery -- prophylaxis; Vaccines -- Periodicals; Vaccination -- Periodicals; 615.37205
• DOI: 10.1080/14760584.2023.2193266
• Languages: English
• ISSNs: 1476-0584

Abstract

ABSTRACT: Introduction: Over the last four decades, human immunodeficiency virus type 1 (HIV-1) infection has been a major public health concern. It is acknowledged that an effective vaccine remains the best hope for eliminating the HIV-1 pandemic. The prophylaxis of HIV-1 infection remains a central theme because of the absence of an available HIV-1 vaccine. The inability of conventional delivery strategies to induce potent immunity is a crucial task to overcome and ultimately lead to a major obstacle in HIV-1 vaccine research. Areas covered: The literature search was conducted in the following databases: PubMed, Web of Science, and Embase. Nano-platforms-based vaccines have proven prophylaxis in various diseases for effectively activating the immune system. Nano-vaccines, including non-viral and viral vectored nano-vaccines, are in a position to improve the effectiveness of HIV-1 antigen delivery and enhance the innate and adaptive immune responses against HIV-1. Compared to traditional vaccination strategies, genetic immunization can elicit a long-term immune response to provide protective immunity for HIV-1 prevention. Expert opinion: Research progress on nano-vaccines for gene delivery against HIV-1 was discussed. Vaccine strategies based on nano-platforms that are being applied to stimulate effective HIV-1-specific cellular and humoral immune responses were particularly emphasized. Graphical Abstract: uf0001