Egg Microneedle for Transdermal Delivery of Active Liraglutide. Issue 9 (20th January 2023)

• Record Type: Journal Article
• Authors: You, Jeongyun; Juhng, Seorin; Song, Jieun; Park, Jihyun; Jang, Mingyu; Kang, Geonwoo; Yang, Huisuk; Min, Hye Su; Shin, Jiwoo; Lee, Seri; Ko, Hyuk Wan; Jung, Hyungil
• Is Part Of: Advanced healthcare materials. Volume 12:Issue 9(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-01-20
• Subjects: drug stability -- liraglutide -- microneedles -- transdermal drug delivery -- type 2 diabetes; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202202473
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: Liraglutide, a human glucagon‐like peptide‐1 (GLP‐1) analog, is promising for safely treating type 2 diabetes mellitus (T2DM), compared to insulin, by significantly reducing the risk of glucose‐dependent hypoglycemia. Concerns related to injection prevent T2DM patients from taking liraglutide regularly, even though once‐a‐day subcutaneous (SC) injections. Dissolving microneedles (DMNs) are promising substitutes for SC injection and for improving patient convenience. However, there are two fundamental limitations: the low drug delivery due to incomplete insertion and loss of drug activity during DMN fabrication. Here, it is shown that an egg microneedle (EMN) designed with three functional layered structures can maintain the maximum activity of the loaded compound during DMN fabrication and deliver it completely into the skin, with the base layer allowing the complete delivery of liraglutide, and the shell layer maintaining the drug activity by mimicking the role of albumin in eggs. In a diabetic mouse model, liraglutide administration via EMN exhibited similar effect when compared to that of injection. Therefore, EMN‐mediated liraglutide administration is a good potential option for replacing liraglutide injections in T2DM treatment. Abstract : A novel multi‐layered egg microneedle (EMN) contains liraglutide drug particle at the center. Such conformation allows EMN to protect the loaded drug by safely covering the drug containing solution immediately after drying. EMN is expected for possible future drug delivery platform with further research.