Dual stimulus-triggered bioorthogonal nanosystem for spatiotemporally controlled prodrug activation and near-infrared fluorescence imaging. Issue 26 (14th March 2023)

• Record Type: Journal Article
• Authors: Zhao, Zhongyi; Zong, Qingyu; Li, Jun; Jiang, Maolin; Wang, Kewei; Yuan, Youyong
• Is Part Of: Chemical communications. Volume 59:Issue 26(2023)
• Page Start: 3878
• Page End: 3881
• Publication Date: 2023-03-14
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d3cc00177f
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Herein, we developed a dual stimulus-triggered bioorthogonal nanosystem that combines low pH and cathepsin B-triggered delivery carriers with a bioorthogonal reaction-activated prodrug and fluorescent probe to enhance tumor therapy and imaging. Abstract : In this study, we combined low pH and cathepsin B dual-stimulus-triggered delivery carriers with a bioorthogonal reaction-activated prodrug to achieve regulated activation of the prodrug. A workable method for precise tumor therapy and imaging is provided by the bioorthogonal reaction, which activates the prodrug and fluorescent probe.