Composite Scaffolds of Gelatin and Fe3O4 Nanoparticles for Magnetic Hyperthermia‐Based Breast Cancer Treatment and Adipose Tissue Regeneration. Issue 9 (10th January 2023)

• Record Type: Journal Article
• Authors: Sun, Rui; Chen, Huajian; Zheng, Jing; Yoshitomi, Toru; Kawazoe, Naoki; Yang, Yingnan; Chen, Guoping
• Is Part Of: Advanced healthcare materials. Volume 12:Issue 9(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-01-10
• Subjects: adipose tissue regeneration -- cancer therapy -- composite scaffolds -- Fe3O4 nanoparticles -- magnetic hyperthermia; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202202604
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: Postsurgical treatment of breast cancer remains a challenge with regard to killing residual cancer cells and regenerating breast defects. To prepare composite scaffolds for postoperative use, gelatin is chemically modified with folic acid (FA) and used for hybridization with citrate‐modified Fe3 O4 nanoparticles (Fe3 O4 ‐citrate NPs) to fabricate Fe3 O4 /gelatin composite scaffolds which pore structures are controlled by free ice microparticles. The composite scaffolds have large spherical pores that are interconnected to facilitate cell entry and exit. The FA‐functionalized composite scaffolds have the ability to capture breast cancer cells. The Fe3 O4 /gelatin composite scaffolds possess a high capacity for magnetic‐thermal conversion to ablate breast cancer cells during alternating magnetic field (AMF) irradiation. In addition, the composite scaffolds facilitate the growth and adipogenesis of mesenchymal stem cells. The composite scaffolds have multiple functions for eradication of residual cancer cells under AMF irradiation and for regeneration of resected adipose tissue when AMF is off. Abstract : Bifunctional composite scaffolds of gelatin and Fe3 O4 nanoparticles are designed to kill breast cancer cells and promote adipose tissue reconstruction. The composite scaffolds can effectively kill breast cancer cells in vitro and in vivo under alternating magnetic field irradiation. Moreover, the composite scaffolds promote lipid oil droplet formation and up‐regulate the expression of adipogenesis‐related genes when alternating magnetic field is off.