Photo-/piezo-activated ultrathin molybdenum disulfide nanomedicine for synergistic tumor therapy. Issue 13 (15th March 2023)

• Record Type: Journal Article
• Authors: Xia, Lili; Chen, Junjie; Xie, Yujie; Zhang, Shan; Xia, Weiwei; Feng, Wei; Chen, Yu
• Is Part Of: Journal of materials chemistry. Volume 11:Issue 13(2023)
• Page Start: 2895
• Page End: 2903
• Publication Date: 2023-03-15
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/d3tb00209h
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : In this study, based on energy-converting nanomedicine, we report multifunctional two-dimensional (2D) molybdenum disulfide (MoS2 ) nanosheets with an inherent plasmonic property and piezocatalytic activity for imaging-guided synergistic tumor therapy. Abstract : Molybdenum disulfide (MoS2 ), as a transition metal dichalcogenide, has attracted tremendous attention owing to its remarkable electronic, physical, and chemical properties. In this study, based on the energy-converting nanomedicine, we report multifunctional two-dimensional (2D) MoS2 nanosheets with inherent plasmonic property and piezocatalytic activity for imaging-guided synergistic tumor therapy. MoS2 nanosheets display strong plasmon resonances in the near-infrared (NIR) region, especially in the second NIR biological window, possessing a notable light energy to heat effect under 1064 nm laser irradiation, which not only serves as a robust photothermal agent for cancer cell ablation but also acts as a contrast-enhanced agent for thermal imaging and photoacoustic imaging. Meanwhile, MoS2 nanosheets feature a remarkable piezotronic effect, exhibiting mechanical vibration energy to electricity under the stimulation of ultrasound-mediated microscopic pressure for reactive oxygen species generation to further kill cancer cells. The new function for old materials may open up the in-depth exploration of MoS2 -based functional biomaterials in the future clinical application of imaging-guided photothermal and piezocatalytic synergetic treatment.