The Gut Microbiome Dynamically Associates with Host Glucose Metabolism throughout Pregnancy: Longitudinal Findings from a Matched Case‐Control Study of Gestational Diabetes Mellitus. Issue 10 (22nd January 2023)

• Record Type: Journal Article
• Authors: Sun, Zhonghan; Pan, Xiong‐Fei; Li, Xiao; Jiang, Limiao; Hu, Ping; Wang, Yi; Ye, Yi; Wu, Ping; Zhao, Bin; Xu, Jianguo; Kong, Mengmeng; Pu, Yanni; Zhao, Manying; Hu, Jianying; Wang, Jinfeng; Chen, Guo‐Chong; Yuan, Changzheng; Yu, Yongfu; Gao, Xiang; Zhao, Fangqing; Pan, An; Zheng, Yan
• Is Part Of: Advanced science. Volume 10:Issue 10(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-01-22
• Subjects: gestational diabetes mellitus -- glucose metabolism -- gut microbiome -- matched case‐control study; Science -- Periodicals; 505
• DOI: 10.1002/advs.202205289
• Languages: English
• ISSNs: 2198-3844

Abstract

Abstract: Though gut microbiome disturbance may be involved in the etiology of gestational diabetes mellitus (GDM), data on the gut microbiome's dynamic change during pregnancy and associations with gestational glucose metabolism are still inadequate. In this prospective study comprising 120 pairs of GDM patients and matched pregnant controls, a decrease in the diversity of gut microbial species and changes in the microbial community composition with advancing gestation are found in controls, while no such trends are observed in GDM patients. Multivariable analysis identifies 10 GDM‐related species (e.g., Alistipes putredinis ), and the integrated associations of these species with glycemic traits are modified by habitual intake of fiber‐rich plant foods. In addition, the microbial metabolic potentials related to fiber fermentation (e.g., mannan degradation pathways) and their key enzymes consistently emerge as associated with both GDM status and glycemic traits. Microbial features especially those involved in fiber fermentation, provide an incremental predictive value in a prediction model with established risk factors of GDM. These data suggest that the gut microbiome remodeling with advancing gestation is different in GDM patients compared with controls, and dietary fiber fermentation contributes to the influence of gut microbiome on gestational glycemic regulation. Abstract : The temporal remodeling in gut microbiota during pregnancy is related to the development of gestational diabetes mellitus (GDM). Habitual intake of fiber‐rich foods modifies the associations of microbial species with glycemic traits during pregnancy. Microbial features measured at early pregnancy provides an incremental predictive value when added to traditional predictive model for GDM risk.