Antioxidase‐Like Nanobiocatalysts with Ultrafast and Reversible Redox‐Centers to Secure Stem Cells and Periodontal Tissues. (22nd January 2023)

• Record Type: Journal Article
• Authors: Guo, Jiusi; Xing, Zhenyu; Liu, Luchang; Sun, Yimin; Zhou, Hongju; Bai, Mingru; Liu, Xikui; Adeli, Mohsen; Cheng, Chong; Han, Xianglong
• Is Part Of: Advanced functional materials. Volume 33:Number 15(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-01-22
• Subjects: artificial nanobiocatalysts -- inflammatory diseases -- nanomedicines -- reactive oxygen species -- stem cell‐based therapies; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.202211778
• Languages: English
• ISSNs: 1616-301X

Abstract

Abstract: Exploration of efficient antioxidase‐like reactive oxygen nanobiocatalysts (ROBCs) is a major challenge in combating oxidative stress‐related diseases. Herein, the molecularly well‐defined Ru‐porphyrin‐networks (Ru‐Por‐Net)‐based ROBCs with ultrafast and reversible redox‐centers for catalytic elimination of reactive oxygen species (ROS) are reported. Owing to the large π‐conjugated networks, Ru–N coordination structures, and unique electronic and redox properties of atomic Ru sites, the Ru‐Por‐Net‐based ROBCs exhibit exceptional catalytic ROS‐scavenging activities. It is considerably more efficient than recently reported state‐of‐the‐art anti‐ROS biocatalysts. Notably, a new nucleophilic attack pathway to eliminate H2 O2 and produce O2 is proposed via theoretical calculations, and the desorption of the OO* process is identified as the rate‐determining step of atomic Ru centers. Cellular studies reveal that the new ROBCs can efficiently secure the survival, adhesion, spreading, and differentiation of the stem cells in high‐ROS‐level microenvironments. In vivo rat periodontitis treatments further demonstrate their superior anti‐ROS therapeutic effects. This study provides significant insights into the crucial functions of Ru–N coordinated porphyrin‐networks in catalytic ROS‐scavenging and offers a new strategy to engineer high‐performance antioxidase‐like nanobiocatalysts for stem cell‐based therapies and inflammatory diseases. Abstract : The molecularly well‐defined Ru‐porphyrin‐networks (Ru‐Por‐Net)‐based reactive oxygen nanobiocatalysts (ROBCs) with ultrafast and reversible redox‐centers are synthesized. Owing to the large π‐conjugated networks, Ru–N coordination structures, and unique electronic and redox properties of Ru sites, these ROBCs exhibit exceptional catalytic elimination activities toward reactive oxygen species (ROS) and efficient anti‐ROS therapeutic effects (rescuing stem‐cell under ROS conditions and treating rat periodontitis).