Autophagy based cellular physiological strategies target oncogenic progression. Issue 1 (26th August 2021)

• Record Type: Journal Article
• Authors: Kumar, Prashant; Jagtap, Yuvraj Anandrao; Patwa, Som Mohanlal; Kinger, Sumit; Dubey, Ankur Rakesh; Prajapati, Vijay Kumar; Dhiman, Rohan; Poluri, Krishna Mohan; Mishra, Amit
• Is Part Of: Journal of cellular physiology. Volume 237:Issue 1(2022)
• Page Start: 258
• Page End: 277
• Publication Date: 2021-08-26
• Subjects: apoptosis -- autophagy -- cancer -- diseases -- tumor; Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.30567
• Languages: English
• ISSNs: 0021-9541

Abstract

Abstract: Evidence accumulated from past findings indicates that defective proteostasis may contribute to risk factors for cancer generation. Irregular assembly of abnormal proteins catalyzes the disturbance of cellular proteostasis and induces the ability of abnormal cellular proliferation. The autophagy mechanism plays a key role in the regular clearance of abnormal/poor lipids, proteins, and various cellular organelles. The results of functional and effective autophagy deliver normal cellular homeostasis, which establishes supportive metabolism and avoids unexpected tumorigenesis events. Still, the precise molecular mechanism of autophagy in tumor suppression has not been clear. How autophagy triggers selective or nonselective bulk degradation to dissipate tumor promotion under stress conditions is not clear. Under proteotoxic insults to knockdown the drive of tumorigenesis, it is critical for us to figure out the detailed molecular functions of autophagy in human cancers. The current article summarizes autophagy‐based theragnostic strategies targeting various phases of tumorigenesis and suggests the preventive roles of autophagy against tumor progression. A better understanding of various molecular partners of autophagic flux will improve and innovate therapeutic approaches based on autophagic‐susceptible effects against cellular oncogenic transformation. Abstract : Deregulated autophagy can cause imperfect aging and cancer Aberrant autophagy may lead to unstable cellular proteome and initiate tumor progression Understanding of autophagy modulation can treat tumor progression Defective cellular proteostasis repair can tackle the cancer problem