Lifetime obesity trends are associated with subclinical myocardial injury: The Trøndelag health study. (19th October 2021)

• Record Type: Journal Article
• Authors: Lyngbakken, Magnus Nakrem; de Lemos, James A.; Hveem, Kristian; Røsjø, Helge; Omland, Torbjørn
• Is Part Of: Journal of internal medicine. Volume 291:Number 3(2022)
• Page Start: 317
• Page End: 326
• Publication Date: 2021-10-19
• Subjects: epidemiology -- troponin -- obesity -- cardiovascular risk factors; Internal medicine -- Periodicals; Medicine -- Periodicals; 616
• DOI: 10.1111/joim.13391
• Languages: English
• ISSNs: 0954-6820

Abstract

Abstract: Background: Obesity is associated with subclinical myocardial injury as quantified by concentrations of cardiac troponin T, but whether lifetime excess weight history is associated with increased concentrations of cardiac troponin I (cTnI) and how indices of abdominal adiposity and glycemic dysregulation affect these associations remain unclear. Methods: We analyzed cTnI with a high‐sensitivity assay in 9739 participants in the Trøndelag Health (HUNT) Study at study visit 4 (2017–2019). BMI was assessed at study Visit 1 (1984–1986), 2 (1995–1997), 3 (2006–2008), and 4. Results: Median age at visit 4 was 68.7 years and 59% were women. Concentrations of cTnI were detectable in 84.1% of study participants, with a median of 2.5 (1.5–4.5 ng/L). We identified three clusters of BMI trajectories from visit 1 to 4, (1) stable normal weight, (2) stable overweight, and (3) stable obesity. Participants in clusters 2 and 3 were at increased risk of elevated concentrations of cTnI at visit 4 (odds ratio 1.27, 95% CI 1.09–1.47, and odds ratio 1.70, 95% CI 1.33–2.17, p for trend <0.001). Participants in cluster 3 had 22.0 (95% CI 14.1–29.9) higher concentrations of cTnI compared to participants in cluster 1 ( p for trend <0.001). Dysregulated glucose metabolism and abdominal obesity did not influence our results. Conclusions: Individuals with stable overweight or obesity are at increased risk of subclinical myocardial injury, independently of glycemic dysregulation and abdominal adiposity. Our data support a direct detrimental effect of long‐standing obesity on cardiovascular health. Abstract :