Regulation of cancer progression by circRNA and functional proteins. Issue 1 (21st October 2021)
- Record Type:
- Journal Article
- Title:
- Regulation of cancer progression by circRNA and functional proteins. Issue 1 (21st October 2021)
- Main Title:
- Regulation of cancer progression by circRNA and functional proteins
- Authors:
- Chen, Junhong
Gu, Jie
Tang, Mengtian
Liao, Zhiqiang
Tang, Rui
Zhou, Lianqing
Su, Min
Jiang, Jiarui
Hu, Yingbin
Chen, Yongyi
Zhou, Yujuan
Liao, Qianjin
Xiong, Wei
Zhou, Jumei
Tang, Yanyan
Nie, Shaolin - Abstract:
- Abstract: Circular RNAs (circRNAs) are closed back‐splicing products of precursor mRNA in eukaryotes. Compared with linear mRNAs, circRNAs have a special structure and stable expression. A large number of studies have provided different regulatory mechanisms of circRNAs in tumors. Challenges exist in understanding the control of circRNAs because of their sequence overlap with linear mRNA. Here, we survey the most recent progress regarding the regulation of circRNA biogenesis by RNA‐binding proteins, one of the vital functional proteins. Furthermore, substantial circRNAs exert compelling biological roles by acting as protein sponges, by being translated themselves or regulating posttranslational modifications of proteins. This review will help further explore more types of functional proteins that interact with circRNA in cancer and reveal other unknown mechanisms of circRNA regulation. Abstract : (1) We highlighted a series of recently emerging studies of circular RNAs (circRNAs) and functional proteins regulating tumorigenesis and cancer progression. (2) RNA‐binding proteins (RBPs) modulate circRNA biogenesis in cancer. (3) CircRNA control posttranslational modification of proteins in cancer.
- Is Part Of:
- Journal of cellular physiology. Volume 237:Issue 1(2022)
- Journal:
- Journal of cellular physiology
- Issue:
- Volume 237:Issue 1(2022)
- Issue Display:
- Volume 237, Issue 1 (2022)
- Year:
- 2022
- Volume:
- 237
- Issue:
- 1
- Issue Sort Value:
- 2022-0237-0001-0000
- Page Start:
- 373
- Page End:
- 388
- Publication Date:
- 2021-10-21
- Subjects:
- biogenesis -- cancer progression -- circular RNAs (circRNAs) -- functional proteins -- RNA‐binding proteins (RBPs)
Physiology -- Periodicals
Cell physiology -- Periodicals
571.6 - Journal URLs:
- http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-4652 ↗
http://onlinelibrary.wiley.com/ ↗ - DOI:
- 10.1002/jcp.30608 ↗
- Languages:
- English
- ISSNs:
- 0021-9541
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 4955.020000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 26885.xml