Colon‐Targeted Adhesive Hydrogel Microsphere for Regulation of Gut Immunity and Flora (Adv. Sci. 18/2021). Issue 18 (22nd September 2021)

• Record Type: Journal Article
• Authors: Liu, Hua; Cai, Zhengwei; Wang, Fei; Hong, Liwen; Deng, Lianfu; Zhong, Jie; Wang, Zhengting; Cui, Wenguo
• Is Part Of: Advanced science. Volume 8:Issue 18(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-09-22
• Subjects: Science -- Periodicals; 505
• DOI: 10.1002/advs.202170115
• Languages: English
• ISSNs: 2198-3844

Abstract

Abstract : Colon‐Targeted Drug Delivery In article number 2101619 by Jie Zhong, Zhengting Wang, Wenguo Cui, and co‐workers, a targeted blasting and adhesive hydrogel microsphere with core‐shell structure is designed for oral administrated inflammatory bowel disease treatment, with a calcium alginate hydrogel shell that targets the colon to "blast" and release the core, and an HA‐SH‐Ag hydrogel core that congregates on the inflamed colon mucosa regulating macrophage differentiation and optimizing the composition of gut flora.