Role of the Synergistic Interactions of Environmental Pollutants in the Development of Cancer. (25th April 2022)

• Record Type: Journal Article
• Authors: Lagunas‐Rangel, Francisco Alejandro; Linnea‐Niemi, Jenni Viivi; Kudłak, Błażej; Williams, Michael J.; Jönsson, Jörgen; Schiöth, Helgi B.
• Is Part Of: GeoHealth. Volume 6:Number 4(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-04-25
• Subjects: pollution -- carcinogens -- reactive oxygen species -- cytochrome P450 -- AhR signaling; Environmental health -- Periodicals; Electronic journals; Periodicals; 616.98
• DOI: 10.1029/2021GH000552
• Languages: English
• ISSNs: 2471-1403

Abstract

Abstract: There is a growing awareness that the large number of environmental pollutants we are exposed to on a daily basis are causing major health problems. Compared to traditional studies that focus on individual pollutants, there are relatively few studies on how pollutants mixtures interact. Several studies have reported a relationship between environmental pollutants and the development of cancer, even when pollutant levels are below toxicity reference values. The possibility of synergistic interactions between different pollutants could explain how even low concentrations can cause major health problems. These intricate that molecular interactions can occur through a wide variety of mechanisms, and our understanding of the physiological effects of mixtures is still limited. The purpose of this paper is to discuss recent reports that address possible synergistic interactions between different types of environmental pollutants that could promote cancer development. Our literature studies suggest that key biological pathways are frequently implicated in such processes. These include increased production of reactive oxygen species, activation by cytochrome P450, and aryl hydrocarbon receptor signaling, among others. We discuss the need to understand individual pathological vulnerability not only in relation to basic genetics and gene expression, but also in terms of measurable exposure to contaminants. We also mention the need for significant improvements in future studies using a multitude of disciplines, such as the development of high‐throughput study models, better tools for quantifying pollutants in cancer patients, innovative pharmacological and toxicological studies, and high‐efficiency computer analysis, which allow us to analyze the molecular mechanisms of mixtures. Plain Language Summary: In general, every day we are exposed to many pollutants at the same time, and each pollutant can interact with others in different ways. Notably, two or more pollutants can interact and enhance their effects through a phenomenon called synergy and this would explain why, even at low concentrations, pollutants can have important health effects. Several studies have reported a link between environmental pollutants and cancer. Thus, our review of the literature suggests that synergy phenomena between pollutants can alter key points in cells and facilitate cancer development. Similarly, we mention the complications and needs to assess these complex interactions in subsequent studies. Key Points: There are an increasing number of reports on the synergetic actions of pollutants in cancer Mixtures of pollutants can interact (synergy/antagonism) affecting different biological pathways Key pathways frequently implicated in synergetic action are reactive oxygen species, cytochrome P450, and aryl hydrocarbon receptor