Anti‐Neuronal Nuclear Antibody 3 Autoimmunity Targets Dachshund Homolog 1. Issue 5 (3rd March 2022)

• Record Type: Journal Article
• Authors: Zekeridou, Anastasia; Yang, Binxia; Lennon, Vanda A.; Guo, Yong; Wu, Liang; Lucchinetti, Claudia F.; McKeon, Andrew; Pittock, Sean J.; Flanagan, Eoin P.
• Is Part Of: Annals of neurology. Volume 91:Issue 5(2022)
• Page Start: 670
• Page End: 675
• Publication Date: 2022-03-03
• Subjects: Neurology -- Periodicals; Pediatric neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; 616.8
• DOI: 10.1002/ana.26320
• Languages: English
• ISSNs: 0364-5134

Abstract

Abstract : The antigen specificity of Anti‐Neuronal Nuclear Antibody‐type 3 (ANNA3)‐IgG is unknown. We identified Dachshund‐homolog 1 (DACH1) as the ANNA3 autoantigen and confirmed it by antigen‐specific assays, immunohistochemical colocalization and immune absorption experiments. Patients' median age was 63.5 years (range, 49–88); 67% were female. Neurological manifestations (information available for 30 patients) included one or more of neuropathy, 12; cognitive difficulties, 11; ataxia, 8; dysautonomia, 7. Evidence of a neoplasm was present in 27 of 30 (90%), most of neuroendocrine lineage. DACH1‐IgG is rare and represents a novel proposed biomarker of neurological autoimmunity and cancer. ANN NEUROL 2022;91:670–675