Toker cell hyperplasia in Zuska disease: A tricky association. (10th November 2020)

• Record Type: Journal Article
• Authors: Torre‐Castro, Juan; Haya‐Martínez, Lara; Ruffin‐Vicente, Belen; Moya‐Martínez, Cristina; Núñez‐Hipólito, Lucía; Díaz de la Pinta, Javier; Cullen‐Aravena, Daniella; Jo‐Velasco, Margarita; Requena, Luis
• Is Part Of: Journal of cutaneous pathology. Volume 48:Number 1(2021)
• Page Start: 180
• Page End: 183
• Publication Date: 2020-11-10
• Subjects: Mammary Paget disease -- Toker cell hyperplasia -- Toker cells -- Zuska disease; Skin -- Diseases -- Periodicals; Dermatology -- Periodicals; 616
• DOI: 10.1111/cup.13908
• Languages: English
• ISSNs: 0303-6987

Abstract

Abstract: Toker cells (TCs) are sometimes present in the nipple epidermis as oval cells with pale cytoplasm and roundish nuclei. In most cases, TCs may be easily distinguished from cancerous cells of Paget disease of the nipple (PCs). Especially in TC hyperplasia, in which mild‐to‐moderate atypia may be present, it may be challenging to distinguish between TCs and PCs. The combination of chronic inflammatory changes in the nipple, in the context of Zuska disease, and TC hyperplasia, may easily lead to an erroneous diagnosis of mammary Paget disease.