Protein‐Based Therapies: Functional Nanocomplexes with Vascular Endothelial Growth Factor A/C Isoforms Improve Collateral Circulation and Cardiac Function (Small 4/2020). Issue 4 (28th January 2020)

• Record Type: Journal Article
• Authors: Qiao, Bokang; Nie, Jing‐Jun; Shao, Yihui; Li, Yulin; Zhang, Congcong; Hao, Wenjing; Li, Sijin; Chen, Dafu; Yu, Bingran; Li, Hui‐Hua; Xu, Fu‐Jian; Du, Jie
• Is Part Of: Small. Volume 16:Issue 4(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-01-28
• Subjects: cardiovascular diseases -- edema -- lymphangiogenesis/angiogenesis -- nanocomplexes -- protein delivery; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.202070019
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract : In article number 1905925, Hui‐Hua Li, Fu‐Jian Xu, Jie Du, and co‐workers use a crosslinked heparin polysaccharide nanoparticle to coordinate delivery of vascular endothelial growth factor A/C (VEGF‐A/C) isoforms to improve cardiac function via intravenous injection at a dose ratio of 3:1 (VEGF‐C vs VEGF‐A). Excellent recovery of cardiac function is successfully demonstrated through improving collateral circulation.