Development and characterization of arteether-loaded nanostructured lipid carriers for the treatment of malaria. (17th February 2016)

• Record Type: Journal Article
• Authors: Ali, Zulfiqar; Mishra, Neeraj; Baldi, Ashish
• Is Part Of: Artificial cells, nanomedicine, and biotechnology. Volume 44:Number 2(2016)
• Page Start: 545
• Page End: 549
• Publication Date: 2016-02-17
• Subjects: arteether -- antimalarial activity -- in vivo studies -- nanolipid carrier -- solubility; Artificial cells -- Periodicals; Nanotechnology -- Periodicals; Blood substitutes -- Periodicals; Tissue engineering -- Periodicals; Molecules -- Periodicals; Biotechnology -- Periodicals; 615.39
• DOI: 10.3109/21691401.2014.968821
• Languages: English
• ISSNs: 2169-1401

Abstract

Abstract : The purpose of the present work is to improve the antimalarial activity of the drug arteether (AE) by enhancing its solubility, by loading it into a nanostructured lipid carrier (NLC). The in vitro drug release profile of the NLC showed 93% drug release in 32 h. Complete eradication of the parasite from the blood and efficient anti-malarial pharmacological activity were observed, with the use of AE-loaded NLCs. These results suggest that nanolipid carriers of AE could be a promising carrier system to deliver the poorly soluble antimalarial drug through the oral route, by enhancing its solubility as well as preventing its degradation in the stomach.