Recent prospective of nanofiber scaffolds fabrication approaches for skin regeneration. (2nd October 2016)

• Record Type: Journal Article
• Authors: Ahmadi-Aghkand, Fateme; Gholizadeh-Ghaleh Aziz, Shiva; Panahi, Yunes; Daraee, Hadis; Gorjikhah, Fateme; Gholizadeh-Ghaleh Aziz, Sara; Hsanzadeh, Arash; Akbarzadeh, Abolfazl
• Is Part Of: Artificial cells, nanomedicine, and biotechnology. Volume 44:Number 7(2016)
• Page Start: 1635
• Page End: 1641
• Publication Date: 2016-10-02
• Subjects: Nanofiber -- scaffolds -- skin regeneration -- tissue engineering -- wound healing; Artificial cells -- Periodicals; Nanotechnology -- Periodicals; Blood substitutes -- Periodicals; Tissue engineering -- Periodicals; Molecules -- Periodicals; Biotechnology -- Periodicals; 615.39
• DOI: 10.3109/21691401.2015.1111232
• Languages: English
• ISSNs: 2169-1401

Abstract

Abstract: The largest organ of human body is skin, which acting as a barrier with immunologic, sensorial and protective functions. It is always in exposure to the external environment, which can result many different types of damage and injury with loss of variable volumes of extracellular matrix (ECM). For the treatment of skin lesions and damages, several approaches are now accessible, such as the application of allografts, autografts, and tissue-engineered substitutes, wound dressings and nanofiber scaffolds approaches. Even though proven clinically effective, these methods are still characterized by main drawbacks such as patient inadequate vascularization, morbidity, the inability to reproduce skin appendages, low adherence to the wound bed and high manufacturing costs. Advanced approaches based on nanofiber scaffolds approaches offer a permanent, viable and effective substitute to explain the drawbacks of skin regeneration and repair by combining growth factors, cells, and biomaterials and advanced biomanufacturing methods. This review details recent advances of nanofiber scaffolds in skin regeneration and repair strategies, and describes a synthesis method of nanofiber scaffolds.