A homogeneous dopamine–silver nanocomposite coating: striking a balance between the antibacterial ability and cytocompatibility of dental implants. (20th October 2022)

• Record Type: Journal Article
• Authors: Wang, Shuang; Wu, Zichen; Wang, Yankai; Hong, Huilei; Zhang, Lijie; Chen, Zhaoyang; Zhang, Pengkang; Chen, Zirui; Zhang, Weibo; Zheng, Shunli; Li, Quanli; Li, Wei; Li, Xiangyang; Qiu, Hua; Chen, Jialong
• Is Part Of: Regenerative biomaterials. Volume 10(2023)
• Publication Date: 2022-10-20
• Subjects: titanium implants -- antibacterial -- cytocompatibility -- silver -- nanocomposites; Biomedical materials -- Periodicals; Regenerative medicine -- Periodicals; 610.284
• DOI: 10.1093/rb/rbac082
• Languages: English
• ISSNs: 2056-3418

Abstract

Abstract: Silver has been widely used for surface modification to prevent implant-associated infections. However, the inherent cytotoxicity of silver greatly limited the scope of its clinical applications. The construction of surfaces with both good antibacterial properties and favorable cytocompatibility still remains a challenge. In this study, a structurally homogeneous dopamine–silver (DA/Ag) nanocomposite was fabricated on the implant surface to balance the antibacterial activity and cytocompatibility of the implant. The results show that the DA/Ag nanocomposites prepared under the acidic conditions (pH = 4) on the titanium surface are homogeneous with higher Ag + content, while an obvious core (AgNPs)–shell (PDA) structure is formed under neutral (pH = 7) and alkaline conditions (pH = 10), and the subsequent heat treatment enhanced the stability of PDA–AgNPs nanocomposite coatings on porous titanium. The antibacterial test, cytotoxicity test, hypodermic implantation and osteogenesis test revealed that the homogeneous PDA–AgNPs nanocomposite coating achieved the balance between the antibacterial ability and cytocompatibility, and had the best outcomes for soft tissue healing and bone formation around the implants. This study provides a facile strategy for preparing silver-loaded surfaces with both good antibacterial effect and favorable cytocompatibility, which is expected to further improve the therapeutic efficacy of silver composite-coated dental implants. Graphical Abstract: