T-cell responses to SARS-CoV-2 in healthy controls and primary immunodeficiency patients. (10th January 2022)

• Record Type: Journal Article
• Authors: Awuah, Arnold; Zamani, Ava; Tahami, Fariba; Davis, Mark; Grandjean, Louis; Buckland, Matthew; Gilmour, Kimberly
• Is Part Of: Clinical and experimental immunology. Volume 207:Number 3(2022)
• Page Start: 336
• Page End: 339
• Publication Date: 2022-01-10
• Subjects: COVID-19 -- SARS-COV2 -- T-cell -- proliferation -- immune deficiency -- immune response -- antibody deficiency; Immunopathology -- Periodicals; 616.079
• DOI: 10.1093/cei/uxac001
• Languages: English
• ISSNs: 0009-9104

Abstract

Abstract: Understanding the T-cell response to SARS-CoV-2 is key in patients who lack antibody production. We demonstrate the applicability of a functional assay to measure the T-cell response in a cohort of patients with immunodeficiency. Abstract : T-cell responses to COVID are now linked to improved outcomes. This paper demonstrates a method to robustly test responses for routine diagnostic use in healthy controls and those unable to make a detectable antibody response due to underlying immune deficiency (primary or acquired). Graphical Abstract: