Meropenem to Treat Valproic Acid Intoxication. Issue 3 (June 2022)

• Record Type: Journal Article
• Authors: Smolders, Elise J.; Ter Heine, Rob; Natsch, Stephanie; Kramers, Kees
• Is Part Of: Therapeutic drug monitoring. Volume 44:Issue 3(2022)
• Page Start: 359
• Page End: 362
• Publication Date: 2022-06
• Subjects: autointoxication -- poisoning -- antiepileptic drug -- mood-stabilizing agent -- valproic acid; Pharmacokinetics -- Periodicals; Patient monitoring -- Periodicals; Drugs -- Analysis -- Periodicals; Body fluids -- Analysis -- Periodicals; Drug Therapy -- Periodicals; Monitoring, Physiologic -- Periodicals; Pharmacology -- Periodicals; 615.7
• DOI: 10.1097/FTD.0000000000000973
• Languages: English
• ISSNs: 0163-4356

Abstract

Abstract: This therapeutic drug monitoring (TDM) grand round describes a patient with serious valproic acid intoxication. A total valproic acid level of 844 mg/L and an unbound valproic acid level of 604 mg/L were observed. Meropenem was administered to enhance the clearance of valproic acid. This off-label usage of meropenem is based on the drug–drug interaction between carbapenems and valproic acid, which reduced the level of valproic acid within 24 hours after administration.