On the Electrophysiology and Mapping of Intramural Arrhythmic Focus. (24th March 2022)

• Record Type: Journal Article
• Authors: Anderson, Robert D.; Rodriguez Padilla, Jairo; Joens, Christian; Masse, Stephane; Bhaskaran, Abhishek; Magtibay, Karl; Niri, Ahmed; Asta, John; Lai, Patrick; Azam, Mohammed Ali; Vigmond, Edward; Nanthakumar, Kumaraswamy
• Is Part Of: Circulation. Volume 15:Number 5(2022)
• Page Start: e010384
• Publication Date: 2022-03-24
• Subjects: catheters -- electrodes -- humans -- endocardium -- pericardium; Arrhythmia -- Periodicals; Heart -- Electric properties -- Periodicals; 616.128
• DOI: 10.1161/CIRCEP.121.010384
• Languages: English
• ISSNs: 1941-3149

Abstract

Abstract : Background: Conventional mapping of focal ventricular arrhythmias relies on unipolar electrogram characteristics and early local activation times. Deep intramural foci are common and associated with high recurrence rates following catheter-based radiofrequency ablation. We assessed the accuracy of unipolar morphological patterns and mapping surface indices to predict the site and depth of ventricular arrhythmogenic focal sources. Methods: An experimental beating-heart model used Langendorff-perfused, healthy swine hearts. A custom 56-pole electrode array catheter was positioned on the left ventricle. A plunge needle was placed perpendicular in the center of the grid to simulate arrhythmic foci at variable depths. Unipolar electrograms and local activation times were generated. Simulation models from 2 human hearts were also included with grids positioned simultaneously on the endocardium-epicardium from multiple left ventricular, septal, and outflow tract sites. Results: A unipolar Q or QS complex lacks specificity for superficial arrhythmic foci, as this morphology pattern occupies a large surface area and is the predominant pattern as intramural depth increases without developing a R component. There is progressive displacement from the arrhythmic focus to the surface exit as intramural focus depth increases. A shorter total activation time over the overlying electrode array, larger surface area within initial 20 ms activation, and a dual surface breakout pattern all indicate a deep focus. Conclusions: Displacement from the focal intramural origin to the exit site on the mapping surface could lead to erroneous lesion delivery strategies. Traditional unipolar electrogram features lack specificity to predict the intramural arrhythmic source; however, novel endocardial-epicardial mapping surface indices can be used to determine the depth of arrhythmic foci.