Spontaneous sensorimotor cortical activity is suppressed by deep brain stimulation in patients with advanced Parkinson's disease. (14th September 2018)

• Record Type: Journal Article
• Authors: Luoma, Jarkko; Pekkonen, Eero; Airaksinen, Katja; Helle, Liisa; Nurminen, Jussi; Taulu, Samu; Mäkelä, Jyrki P.
• Is Part Of: Neuroscience letters. Volume 683(2018)
• Page Start: 48
• Page End: 53
• Publication Date: 2018-09-14
• Subjects: Magnetoencephalography -- Subthalamic nucleus -- Advanced Parkinson's disease -- Deep brain stimulation -- Beta band suppression; Neurology -- Periodicals; Neurology -- Periodicals; Research -- Periodicals; Neurologie -- Périodiques; Neuroanatomie -- Périodiques; Neuropharmacologie -- Périodiques; Neurophysiologie -- Périodiques; Neurology; Periodicals; Electronic journals; 617.48
• DOI: 10.1016/j.neulet.2018.06.041
• Languages: English
• ISSNs: 0304-3940

Abstract

Highlights: Deep brain stimulation (DBS) of subthalamic nucleus suppresses 5–25 Hz cortical oscillations in Parkinson's disease (PD) patients. The effect exceeds the sensorimotor region estimated by analysis of corticomuscular coherence. DBS may alleviate motor symptoms in PD by reducing pathological synchrony in the sensorimotor network. Abstract: Advanced Parkinson's disease (PD) is characterized by an excessive oscillatory beta band activity in the subthalamic nucleus (STN). Deep brain stimulation (DBS) of STN alleviates motor symptoms in PD and suppresses the STN beta band activity. The effect of DBS on cortical sensorimotor activity is more ambiguous; both increases and decreases of beta band activity have been reported. Non-invasive studies with simultaneous DBS are problematic due to DBS-induced artifacts. We recorded magnetoencephalography (MEG) from 16 advanced PD patients with and without STN DBS during rest and wrist extension. The strong magnetic artifacts related to stimulation were removed by temporal signal space separation. MEG oscillatory activity at 5–25 Hz was suppressed during DBS in a widespread frontoparietal region, including the sensorimotor cortex identified by the cortico-muscular coherence. The strength of suppression did not correlate with clinical improvement. Our results indicate that alpha and beta band oscillations are suppressed at the frontoparietal cortex by STN DBS in PD.