Chitosan nanoparticles loaded hydrogels promote skin wound healing through the modulation of reactive oxygen species. (31st October 2018)

• Record Type: Journal Article
• Authors: Wang, Tao; Zheng, Yan; Shen, Yaping; Shi, Yijie; Li, Fang; Su, Chang; Zhao, Liang
• Is Part Of: Artificial cells, nanomedicine, and biotechnology. Volume 46(2018)Supplement 1
• Page Start: 138
• Page End: 149
• Publication Date: 2018-10-31
• Subjects: Inflammation -- neovascularization -- chitosan -- nanoparticles -- calcium alginate hydrogel; Artificial cells -- Periodicals; Nanotechnology -- Periodicals; Blood substitutes -- Periodicals; Tissue engineering -- Periodicals; Molecules -- Periodicals; Biotechnology -- Periodicals; 615.39
• DOI: 10.1080/21691401.2017.1415212
• Languages: English
• ISSNs: 2169-1401

Abstract

Abstract: This study developed a novel bioactive chitosan nanoparticle loaded calcium alginate hydrogel to regulate inflammation and neovascularization for accelerated wound healing in vivo . It was found that chitosan nanoparticles loaded calcium alginate hydrogel exhibited remarkable antibacterial activity. Through the modulation of generation of ROS, it promoted the synthesis and secretion of IL-6 in vascular endothelial cell (VEC), suggesting its potential proinflammatory activation. Further, it promoted VEC invasion, metastasis and neovascularization to accelerate wound healing.