Radiosensitivity enhancement of Fe3O4@Ag nanoparticles on human glioblastoma cells. (31st October 2018)

• Record Type: Journal Article
• Authors: Zhang, Xiaohong; Liu, Zhujun; Lou, Zhichao; Chen, Feng; Chang, Shuquan; Miao, Yuji; Zhou, Zhuo; Hu, Xiaodan; Feng, Jundong; Ding, Qi; Liu, Peidang; Gu, Ning; Zhang, Haiqian
• Is Part Of: Artificial cells, nanomedicine, and biotechnology. Volume 46(2018)Supplement 1
• Page Start: 975
• Page End: 984
• Publication Date: 2018-10-31
• Subjects: Radiotherapy -- radiosensitivity -- Fe3O4@Ag nanoparticles -- autophagy -- apoptosis; Artificial cells -- Periodicals; Nanotechnology -- Periodicals; Blood substitutes -- Periodicals; Tissue engineering -- Periodicals; Molecules -- Periodicals; Biotechnology -- Periodicals; 615.39
• DOI: 10.1080/21691401.2018.1439843
• Languages: English
• ISSNs: 2169-1401

Abstract

Abstract: Radiotherapy is one of the main therapeutic methods for cancers, but radiation resistance of cancer cells still remains a serious concern. Searching for radiosensitizers to overcome such resistance is therefore urgently required. The goal of this study is to evaluate and compare the radiosensitizing efficacy of Fe3 O4 -OA, Ag and Fe3 O4 @Ag nanoparticles on U251 cells. The results show that Fe3 O4 @Ag nanoparticles have the highest ability of radiosensitization among the three nanoparticles. The underlying mechanism of Fe3 O4 @Ag nanoparticles' radiosensitivity enhancement is through decrease of the cytoprotective autophagy at the early stage, and increase of the calcium-dependent apoptosis at the later stage. These findings suggest the potential application of Fe3 O4 @Ag nanoparticles as a highly effective nano-radiosensitizer for the treatment of glioblastoma cells. Graphical Abstract: UF0001