Recent treatment modalities for cardiovascular diseases with a focus on stem cells, aptamers, exosomes and nanomedicine. (31st October 2018)

• Record Type: Journal Article
• Authors: Mittal, Rahul; Jhaveri, Vasanti M.; McMurry, Hannah S.; Kay, Sae-In Samantha; Sutherland, Kyle J.; Nicole, Lin; Mittal, Jeenu; Jayant, Rahul Dev
• Is Part Of: Artificial cells, nanomedicine, and biotechnology. Volume 46(2018)Supplement 1
• Page Start: 831
• Page End: 840
• Publication Date: 2018-10-31
• Subjects: Cardiovascular diseases -- treatment modalities -- exosomes -- stem cells -- aptamers -- immunotherapy -- nanomedicine; Artificial cells -- Periodicals; Nanotechnology -- Periodicals; Blood substitutes -- Periodicals; Tissue engineering -- Periodicals; Molecules -- Periodicals; Biotechnology -- Periodicals; 615.39
• DOI: 10.1080/21691401.2018.1436555
• Languages: English
• ISSNs: 2169-1401

Abstract

Abstract: Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide. Due to the significant impact of CVD on humans, there is a need to develop novel treatment modalities tailored to major classes of cardiac diseases including hypertension, coronary artery disease, cardiomyopathies, arrhythmias, valvular disease and inflammatory diseases. In this article, we discuss recent advancements regarding development of therapeutic strategies based on stem cells, aptamers, exosomes, drug-eluting and dissolvable stents, immunotherapy and nanomedicine for the treatment of CVD. We summarize current research and clinical advances in cardiovascular therapeutics, with a focus on therapies that move beyond current oral- or sublingual-based regimens. This review article provides insight into current research and future treatment strategies that hold a great relevance for future clinical practice in pursuit of improving quality of life of patients suffering from CVD.