Deep learning approach to predict lymph node metastasis directly from primary tumour histology in prostate cancer. (5th May 2021)

• Record Type: Journal Article
• Authors: Wessels, Frederik; Schmitt, Max; Krieghoff‐Henning, Eva; Jutzi, Tanja; Worst, Thomas S.; Waldbillig, Frank; Neuberger, Manuel; Maron, Roman C.; Steeg, Matthias; Gaiser, Timo; Hekler, Achim; Utikal, Jochen S.; von Kalle, Christof; Fröhling, Stefan; Michel, Maurice S.; Nuhn, Philipp; Brinker, Titus J.
• Is Part Of: BJU international. Volume 128:Number 3(2021)
• Page Start: 352
• Page End: 360
• Publication Date: 2021-05-05
• Subjects: prostatic neoplasms -- machine learning -- deep learning -- artificial intelligence -- convolutional neural network -- neoplasm metastasis -- #ProstateCancer -- #PCSM -- #uroonc; Genitourinary organs -- Diseases -- Periodicals; Genitourinary organs -- Surgery -- Periodicals; Urology -- Periodicals; 616.6
• DOI: 10.1111/bju.15386
• Languages: English
• ISSNs: 1464-4096

Abstract

Abstract : Objective: To develop a new digital biomarker based on the analysis of primary tumour tissue by a convolutional neural network (CNN) to predict lymph node metastasis (LNM) in a cohort matched for already established risk factors. Patients and Methods: Haematoxylin and eosin (H&E) stained primary tumour slides from 218 patients (102 N+; 116 N0), matched for Gleason score, tumour size, venous invasion, perineural invasion and age, who underwent radical prostatectomy were selected to train a CNN and evaluate its ability to predict LN status. Results: With 10 models trained with the same data, a mean area under the receiver operating characteristic curve (AUROC) of 0.68 (95% confidence interval [CI] 0.678–0.682) and a mean balanced accuracy of 61.37% (95% CI 60.05–62.69%) was achieved. The mean sensitivity and specificity was 53.09% (95% CI 49.77–56.41%) and 69.65% (95% CI 68.21–71.1%), respectively. These results were confirmed via cross‐validation. The probability score for LNM prediction was significantly higher on image sections from N+ samples (mean [SD] N+ probability score 0.58 [0.17] vs 0.47 [0.15] N0 probability score, P = 0.002). In multivariable analysis, the probability score of the CNN (odds ratio [OR] 1.04 per percentage probability, 95% CI 1.02–1.08; P = 0.04) and lymphovascular invasion (OR 11.73, 95% CI 3.96–35.7; P < 0.001) proved to be independent predictors for LNM. Conclusion: In our present study, CNN‐based image analyses showed promising results as a potential novel low‐cost method to extract relevant prognostic information directly from H&E histology to predict the LN status of patients with prostate cancer. Our ubiquitously available technique might contribute to an improved LN status prediction.