Bioactive glass ions hydrogels with antiinflammation antioxidant capacity for treating inflammation-related diseases. (March 2023)

• Record Type: Journal Article
• Authors: Liu, Wenguang; Chen, Mi; Luo, Meng; Li, Ting; Hu, Chaoyan; Xie, Chenxi; Li, Sihua; Leng, Tongtong; Tian, Jing; Xu, Peng; Lei, Bo
• Is Part Of: Materials & design. Volume 227(2023)
• Publication Date: 2023-03
• Subjects: Bioactive glass nanoparticle -- Bioactive ions hydrogel -- Multifunctional -- Inflammatory diseases; Materials -- Periodicals; Engineering design -- Periodicals; Matériaux -- Périodiques; Conception technique -- Périodiques; Electronic journals; 620.11
• DOI: 10.1016/j.matdes.2023.111669
• Languages: English
• ISSNs: 0264-1275

Abstract

Graphical abstract: Highlights: Antiinflammatory antioxidant angiogenetic bioactive glass derive ions-based hydrogels were fabricated. The 6 times diluted medium-derived hydrogel contributed antiinflammation in vivo and in vitro . Bioactive ions hydrogels stimulated M2 macrophage derived anti-inflammation exosome secretion in rheumatoid arthritis therapy. 25 mg/L of silicon content in bioactive nanoglass ions exhibited antiinflammation antioxidant angiogenetic function in vitro . Abstract: Inflammation-related infected wound and rheumatoid arthritis (RA) are still the challenge in biomedical filed. Bioactive molecules and materials are showing much interest in treating inflammation-related diseases. Herein, we report an antiinflammatory antioxidant angiogenetic bioactive ions-based scaffold based on the bioactive nanoglass for treating methicillin-resistant staphylococcus aureus (MRSA) infected wound and RA. It was found that the bioactive nanoglass ions (BNGI) with 3 × and 6 × dilution demonstrated the significant anti-inflammation ability (the inhibition of Tnf-α and IL1β ), macrophage polarization function (the decrease of CD86 + cells), antioxidant and angiogenic capacities (the increased node number, branching length and CD31 expression). 1 × diluted BNGI-derived Pluronic F127 and gelatin methacryloyl hydrogels could significantly enhance the MRSA-infected wound healing and attenuate the RA progression through stimulating the secretion of antiinflammation exosomes from macrophage (3-fold upregulation compared with 3M TM dressing) and proper angiogenesis based on the important role of silicon (about 150 mg/L in vivo and 25.4 to 48.1 mg/L in vitro ) in BNGI. Our findings revealed the therapeutic function and potential mechanism of BNGI in inflammatory diseases and tissue engineering.