Bis(azolyl)pyridine‐2, 6‐dicarboxamide Derivatives: Synthesis, Bioassay Analysis and Molecular Docking Studies. Issue 12 (22nd March 2023)

• Record Type: Journal Article
• Authors: Bharath kumar, Momidi; Hariprasad, Vanam; Joshi, Shrinivas D; Jayaprakash, Gururaj Kadur; L., Parashuram; Pani, A. Saranga; Babu, Dickson D.; Naik, Praveen
• Is Part Of: ChemistrySelect. Volume 8:Issue 12(2023)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2023-03-22
• Subjects: Azoles -- Antioxidant activity -- Antimicrobial activity -- Molecular docking studies -- Pyridine; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.202204927
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: A new class of bis(azolyl) pyridine‐2, 6‐dicarboxamides based derivatives were designed and synthesized by employing ultrasonication methodology. In this work, we studied the role of different heteroaromatic azole units such as oxazole, thiazole and imidazole moieties along with different donating/withdrawing substituents on the pyridine scaffold and anticipated to display good biological activities. The detailed molecular docking studies validates the antimicrobial activities of these targeted molecules. Further, to evaluate their antioxidant properties, the target compounds were exposed to three different invitro free radical scavenging assay methods. Further, using the disc diffusion method, the targeted molecules were screened for invitro antibacterial activities against the pathogenic stains. Besides, the targeted molecules were also tested against A. niger and P. chrysogenum strains to assess their antifungal activity. The screening results reveals that, the most of the compounds form the series demonstrating reasonable to decent antioxidant and antimicrobial activities against pathogenic stains in comparison with the standard drug. Abstract : A new class of bis(azolyl) pyridine‐2, 6‐dicarboxamides based derivatives were designed, synthesized, and characterized by employing ultrasonication methodology. The screening results reveals that, the most of the synthesized compounds possess good antibacterial, antioxidant and antifungal activities in comparison with the standard drug.